What went wrong in Oxford :) and learning to move forward, embracing the past hiccups. :p

So about what went wrong in Oxford.. πŸ™‚ Btw, my old uni isn’t particularly bad :p as it dares to compete with Cambridge. πŸ™‚ xoxo i was found by Mark before Oxford took a notice of me starting
@insilicogenesis… Oxford taught me many good things and it’s beautiful too.


Dark Blue gave me access to the uni’s supercomputing facilities and i shared all my files on the system – what i could do for them. They taught me the default position: female needing to be more aggressive πŸ™‚ and talk only about money or fundraising, if you wanted to be taken seriously by the important people in the power circuit.

Basically, don’t be me – i am not into any of that. i wanted to do this, as this way gives me freedom to do what i am interested in and you can cross from infectious diseases to Alzheimer’s work & onto a rare ageing disease.

So i was doing what my old uni taught me πŸ™‚ when Mark sat me down.. He paused and asked me : What is it that you want to do? i knew what i wanted but i looked him in the eye… Oxford taught me not to talk like that… πŸ™‚ Also, i want the freedom as i want to answer one question.

How did God do Genesis? i believe that there is a way to explore that, through genomics and an understanding of protein folding – something read in by all living organisms and yet we are missing on it from the way we build 3D structures.

Publishing papers don’t excite me as it should, which is a serious problem :p and i want to get there not by publishing papers endlessly but by bringing out meds that are needed in the real world.. The diseases or their targets are so interconnected – it’s not like the book or how do you solve it if you only have to look at the scope predefined by the departments assigned? So i shut that up πŸ™‚ and people can think of whatever they want to perceive of little me.. So i was trying to be what Oxford typically nurtures and there are good Oxford people..

It’s not Dark Blue. It’s me – something inside me doesn’t fit in. Either they will have to suppress what’s undeniably in me or i deny what i really am, to fit into how Oxford works, which works well clearly.. πŸ™‚ And, in the end, you need to work with people who think & love life sciences, whether they might be your potential investors who do not need to share your day-to-day research at all – i learnt it hard way – it drains you, though they are good people – it’s a bottomless drainage, not efficient nor effective..

Less money with people who really understand what you are trying to solve is far more effective.. i thought wrong: i thought their enthusiasm and open mind would suffice. i could only get to just before finalising the funding at the board levels and easy to get NDAs but stuck at business development meetings.. πŸ™‚

Mark wanted to help just around there.. πŸ™‚ i knew they wouldn’t be happy if Mark was fully brought in… Dr. Mark Treherne has a huge fearful reputation in the territory of Dark Blue. Mark was always busy with many companies & projects. So i made that idiot decision. So my fault.

BBI Open Day in Cambridge! (11/Aug/2021)

So what i was taught yesterday πŸ™‚ Not just owning what went wrong in your earlier life but go further – honour it :p in your heart. If you can be that positive inside, your attitude will be seen as the surest guarantee for a greater success fast incoming for the future. πŸ™‚

Obviously, Mark was talking about work πŸ™‚ and i have loads to that direction. :p But for me, this comes before any of that stuff.. Last time Mark asked me an important question in his own way right after that magnificent moment (skip the details. πŸ™‚ i went so utterly wrong.

He talks like a medieval king in private with little me and i don’t always get it – i hear it and i go – never heard anyone else speaking that way before… So i didn’t get it at all.. but i figured a moment later, in his eyes, as i clearly answered horribly wrong. That really went wrong… xoxo i was so overwhelmed with the first time in my whole i felt that i am built okay inside to receive a male properly.. i always thought there was something wrong with me as i couldn’t.. i was in heaven and i meant that but i didn’t explain any of that..

It took me years, literally πŸ™‚ to open up to Mark about that, which came out at a worst possible moment conceivable.. Really, that bad a moment it could have ever been.. Right. Now the rest that went wrong in Oxford is a piece of cake to talk about, in comparison.. πŸ™‚ okay. xxx

A little update – the excerpts taken from LinkedIn posts. :)

mark7

Fantastic. πŸ™‚ A baby biotech to something like Facebook just within years, and then beyond something like Amazon over the years. Those are all like from being nowhere to where they are in a fraction of what took Microsoft ..

So somehow the operation will need to differ from a biotech, being a baby biotech and not the path like becoming GSK or AZ, though that’s how a biotech would normally look up to. But not that way.

It would be fun and who knows UK will do that before the US, unlike Facebook, Google, or Amazon all being US IT-based start-ups a short while ago or in just about a baby growing to a teenager or a college kid timelines..

Somebody told me that i am that ages ago then i went dormant from that point.. πŸ™‚ Am possibly beginning to wake up and believe what they saw in me years ago. πŸ™‚ πŸ’•

Jonathan2020

Most of the things that was taught, not that way πŸ™‚ i was just one of the many Oxford uni students who happened to be sent to Cambridge rather often for my bioinformatics learning.. Then, i was sent to Heidelberg often as well, because EMBL has a strong base, closer to experimental structural biology.. a little different from EBI’s approach – both are good.

Always funded πŸ™‚ as in everything free for me :p by the EU and the MRC would cover any costs for anywhere so i would attend these nerdy πŸ™‚ courses in Manchester, Leeds & Sheffield.. primarily in Cambridge always, which is why i am so familiar with drummer street and the shops behind it.. :p

Stagecoach runs something really cheap for uni kids or people. πŸ™‚ i think it still runs.. :p i didn’t have many who shared the sort of work that i was trained for in Oxford, as that line of bioinformatics is a bit a low grade :p and boring πŸ™‚ so i was alone a lot at Oxford and sent away very often.

Oxford is brilliant in lots of ways in this area, and i believe their approach slightly differs from that of Cambridge. πŸ™‚ So i was all the more alone at Oxford, because my work looked boring to brilliant Oxford students mostly and i found it inside of me, like this is it. :p

mark7

Little me didn’t know, all those years in Britain.. Then, he told me – why don’t you go to .. πŸ‡°πŸ‡· for a while, quite some time ago.. i didn’t want to right on spot as England has always been easier & far more comfortable for little me to be just who i am.. πŸ’•
Always kinder & sweeter with me… Brits just understand me, unfailingly, white born & bred ones in particular.. i was worried about going to πŸ‡°πŸ‡· as i lost their language a lot.. Speaking & writing would stress me out.. Reading would suffocate me and sometimes, i wished i hadn’t understood what i heard.. it got better a bit.. πŸ™‚
You read a word & no idea what that is.. πŸ™‚ You hear & you get a feeling of good or bad but no idea as to how to respond to it.. Keep on asking.. sorry? what? again please? you still don’t hear.. i ask them to write it down, when possible.. πŸ™‚
Other times, you hear it and know that is a foreign language. Then, almost 5 min gone, i recognise that was Korean being spoken the whole time.. Can you guess how that might have felt to me.. That wasn’t the point at all.. πŸ™‚ Sorry for the side-tracking.. xxx

Almost by accident, little me noticed that the EU has long been very kind with πŸ‡°πŸ‡· … So, thank you for being good to my motherland. πŸ’•

happy_Hyunji

Then, just too vivid to be dreams that I had years earlier, like visions just way too specific.. to call those a dream in sleep. What I meant πŸ™‚ was .. with the family growing and growing up :p, i work – am definitely working but always home, doing the work that i do, whilst fixing something for the family in the kitchen or am home in the daytime .. and attend to the son’s homework or am on the phone with my laptop on, with the boys playing together in that far end corner of a huge living room..

Or he pops in for whatever in the kitchen or work together at home and sometimes have small meetings with typically one other person with us.. Couldn’t make sense of those dreams as i had them before this Corona pandemic happened..

Now, they sort of look alright ish.. i used to think.. – how is that possible or what sort of work/home would possibly allow such degrees of flexibility and so utterly family-friendly.. but in those, I always work but am always home πŸ™‚ except for being out with him.. πŸ™‚

With this corona … what felt so weird almost look – okay, that might work. πŸ™‚ (i must stop talking – it’s late .. and Fri.. πŸ™‚ Have a lovely weekend, everyone! πŸ’•xoxoπŸ’•)

**We have had lost babies in pregnancy, before this pandemic gripping the world. There is a hope for the future, right through the pandemic and all. :p xxx

**With God’s Grace upon us. πŸ’•xoxoπŸ’•

Anna2020

Tiny thoughts on Covid19, taken from @insilicogenesis on Twitter

On a quite separate note, Oxford is only my old uni after all, and Dylan was safely born at the uni’s hospital. As much as I hope for the success of the uni’s vaccine candidate currently ongoing, just some minor concerns if I may share them here..Β  β™₯my old uni not bad at this. β™₯

70% of people developed a fever? With this coronavirus, the first screening point is a body temperature above 37.5 degrees in Celsius.. Plus headache? How different is their side effect from the mild symptoms of Covid19 then? The foremost screening is the mild fever with Covid19..

So their vector is a pathogenic virus in Chimp? That’s very close to human. Because we have this situation due to a zoonotic capacity of an animal virus, which should not have affected any ethnicity of the human race in principle but it did.

And they worried about that possibility enough to heavily modify their chosen pathogenic virus, genetically, to put that in human body? This is rushed because we need a vaccine? How much testing is done, about those genetic modifications done to this disease-causing Chimp virus?

If those are no cause for concerns at all and just little me fussing over potential dangers, there was this webinar on this virus in the spring from the US. Covid19 is capable of bypassing Spike protein to invade host cells. It doesn’t have to rely on that protein to attack us.

— The above thread was printed on Twitter, dated 23/Jul/2020.

cropped-uk2020-2.jpeg

ISG presents in One Nucleus CNS Leadership Seminar series in London.

In Silico Genesis presented our Alzheimer’s strategy to the One Nucleus CNS Leadership Seminar Series held in London, on the 11th of Feb. 2013.

isg_on2

This seminar will look at:

β€’ The Prime Minister’s Dementia Challenge
β€’ Pharmacotherapy for Alzheimer’s disease – progress and prospects
β€’ The emerging scientific advances that may enable greater success in the future

Agenda:

10.30 – Registration

11.00 – Welcome from the Chair
Janet Knowles, Partner, Eversheds

11.10 – The Prime Minister’s Dementia Challenge
Mark Treherne, CEO, Life Sciences Investment Organisation, UKTI

11.30 – What are the prospects of slowing the progression of Alzheimer’s disease?
Prof Alan Palmer, Director MS Therapeutics

12.00 – What insights do biomarkers provide into the recent Phase III failures?
Andrea Les, Senior Imaging Scientist, IXICO

12.20 – Q&A with the speakers

12.45 – Networking Lunch

13.45 – Introduction from the Chair
Philip Oliver

13.45 Is there a future for the amyloid theory in treating Alzheimer’s disease?
Eric Karran, Alzheimer’s Research UK

14.05 Targeting Tau hyperphosporylation in AD
Ian Pike, COO, Proteome Sciences

14.25 – Genetic basis of Alzheimer disease susceptibility
Prof. Julie Williams, Cardiff University School of Medicine

14.45 – FGL Peptides as neuroprotectives in AD
Steve Rees, COO, ENKAM Pharmaceuticals A/S

15.05 – Translational genomic medicine and companion diagnostic development
Kimberley Treherne
(then, Williams), In Silico Genesis

15.25 – Closing Remarks from one Nucleus
Tony Jones, Director of Business Development, One Nucleus

15.30 – Networking drinks

16.30 – Close

Shown above can be found at http://onenucleus.com/onenucleus-events?id=692.

ISG signs CDA with Oxford University Innovation (previously known as ISIS Innovation), the University of Oxford and Baroness Susan Greenfield.

In Silico Genesis signed up a Confidential Disclosure Agreement with ISIS Innovation, the commercial arm of the University of Oxford, and the University of Oxford and plus Baroness Professor Susan Greenfield of Pharmacology of the University of Oxford in June 2013. This 4 way CDA was put in place, following an initial collaborative work with Prof. Greenfield’s lab on a repurposed drug for Alzheimer’s Disease.

ISG signs CDA with Public Health England, Department of Health under HM Government.

In Silico Genesis signed up a Confidential Disclosure Agreement with Public Health England (PHE), previously Health Protection Agency, in June 2013. This CDA was reaffirming an initial CDA placed in October, 2011 between Health Protection Agency (HPA) and In Silico Genesis (ISG) about the antiviral work in collaboration.Β 

Public Health England (PHE) https://www.gov.uk/government/organisations/public-health-england

ISG signs NDA contract with University of Bristol, relating to research for influenza virus treatments.

In Silico Genesis signed up NDA contract (Confidentiality Agreement) with University of Bristol, following initial discussions with faculty members of Centre for Computational Chemistry, School of Chemistry, University of Bristol, England in May/June 2013. This NDA contract was communicated via Research Enterprise Development, on behalf of the Department of Chemistry, for the official signatory of the University of Bristol. This confidentiality agreement bears a specific scope of the permitted purpose, which is relating to research on potential drugs for new medicinal targets for influenza treatments.

We met at e-Infrastructure South Conference and his presentation was of great interest to the work of In Silico Genesis, in the area of the current drug resistance of the existing flu medicines and how it can be alleviated. In order to achieve this, it is necessary to understand what it is causing the resistance at the structural level. His work was spot on, beautifully so.

What was more impressive still, was how the University of Bristol handled the NDA contract, in a most professional and thorough manner. At the time, I was sceptical of anything that was from outside of my Oxford University. They showed me the grace and understanding, instead of walking away from what could have been very unpleasant to them. For that, I am thankful to the University of Bristol, regardless of what may become of this NDA contract in the years to come.

In Silico Genesis signs CDA with Imanova (Centre for Imaging Sciences), a spin-off from GlaxoSmithKline

In Silico Genesis signed up a Confidential Disclosure Agreement with Imanova, a spin-off company from GlaxoSmithKline (GSK), in April 2015. This CDA was originally signed by the CEO of Imanova on the 19th of April 2013, following a mutual interest identified in the area of CNS, whilst both companies attending One Nucleus CNS Leadership Seminar series in London on the 11th of February 2013.

Since then, Imanova and In Silico Genesis have both been selected to represent the strengths of British companies on the UK Trade and Investment CNS Trade Mission to British Embassy Seoul and British Embassy Tokyo, in the first week of November 2014. I was very impressed by the quality of the work presented by Imanova, and more so by his warmth and genuine respect which he showed to the people of South Korea and of Japan at the Embassies.

I had the pleasure of introducing my father to the CEO of Imanova at British Embassy Seoul. Then, I was deeply touched by how he opened his seminar at British Embassy Tokyo, sharing with the audience openly what Japan really meant to him and his daughter. I returned my signed copy of the original CDA bearing his signature, to the CEO of Imanova on the 19th of April, 2015. He is a hard-working CEO and believes in what Imanova can do to help people.

Happy New Year from In Silico Genesis!

Hello World. Blessings and peace be unto you and all your beloved in abundance this year. May the almighty creator God gives you joy, happiness and exceedingly abundant above goodness over your life and every walk of your path.

In Silico Genesis has had a good start of this new year 2015. We are very thankful to the UK Trade and Investment & One Nucleus, respectively, for approaching In Silico Genesis to follow up on the UKTI CNS Trade Mission, which took place in November 2014 at British Embassy Seoul and British Embassy Tokyo. It is such a pleasure to be asked to report back the good things that the UKTI has done for In Silico Genesis, by both organisations. I am grateful. I give praise and thanks to my almighty God for the exceeding goodness that He brings to In Silico Genesis. Glory to God.

My father took this picture, when he accompanied me to British Embassy Seoul, representing In Silico Genesis together with me.

The British Ambassador to South Korea with me (the curly blonde in the centre) at British Embassy Seoul, on the UKTI CNS Trade Mission.
The British Ambassador to South Korea with me (the curly blonde in the centre) at British Embassy Seoul, on the UKTI CNS Trade Mission.

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